SLC19A1 anticorps (N-Term)
(2 références)Aperçu rapide pour SLC19A1 anticorps (N-Term) (ABIN310565)
Antigène
Voir toutes SLC19A1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
-
-
Épitope
- N-Term
-
Séquence
- MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
-
Homologie
- Human: 100%
-
Attributs du produit
- This is a rabbit polyclonal antibody against SLC19A1. It was validated on Western Blot and immunohistochemistry.
-
Purification
- Protein A purified
-
Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human SLC19A1
-
-
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 412-426), (Extracellular) antibody
SLC19A1 Reactivité: Souris WB, IHC, FACS Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibodySLC19A1 Reactivité: Humain WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibodySLC19A1 Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 202-231), (Middle Region) antibodySLC19A1 Reactivité: Souris, Rat, Humain, Singe WB Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 101-200) antibodySLC19A1 Reactivité: Souris WB, ICC, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 452-591) antibodySLC19A1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (AA 198-231) antibodySLC19A1 Reactivité: Humain WB, ELISA, FACS Hôte: Lapin Polyclonal unconjugated
-
-
Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
-
Commentaires
-
Antigen size: 591 AA
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Concentration
- Lot specific
-
Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
Agent conservateur
- Sodium azide
-
Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
-
Stock
- -20 °C
-
Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
-
-
: "The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier." dans: Molecular pharmacology, Vol. 80, Issue 4, pp. 621-9, (2011) (PubMed).
: "Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 14, pp. 3648-58, (2010) (PubMed).
-
-
- SLC19A1 (Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1))
-
Autre désignation
- SLC19A1
-
Sujet
-
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. SLC19A1 plays a role in maintaining intracellular concentrations of folate.Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM].
Alias Symbols: CHMD, FOLT, IFC1, REFC, RFC1
Protein Interaction Partner: UBC,
Protein Size: 591 -
Poids moléculaire
- 65 kDa
-
ID gène
- 6573
-
NCBI Accession
- NM_194255, NP_919231
-
UniProt
- P41440
-
Pathways
- Dicarboxylic Acid Transport
Antigène
-
