TIMP3 anticorps
Aperçu rapide pour TIMP3 anticorps (ABIN498405)
Antigène
Voir toutes TIMP3 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects endogenous levels of TIMP-3 protein. (region surrounding asn119)
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Réactivité croisée (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
Purification
- Affinity Chromatography using epitope-specific immunogen.
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anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 113-139) antibody
TIMP3 Reactivité: Humain, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB21049 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 26-211) antibodyTIMP3 Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 151-211) antibodyTIMP3 Reactivité: Humain, Rat, Lapin WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 170-188) antibodyTIMP3 Reactivité: Humain, Boeuf (Vache), Chien, Cheval, Mouton, Porc, Singe WB, IHC, IHC (p), IHC (fro) Hôte: Souris Monoclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 27-209) antibodyTIMP3 Reactivité: Rat WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 119-148), (Middle Region) antibodyTIMP3 Reactivité: Humain WB, FACS, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 176-210), (C-Term) antibodyTIMP3 Reactivité: Humain WB Hôte: Lapin Polyclonal RB47669 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 112-211) antibodyTIMP3 Reactivité: Humain ELISA Hôte: Souris Monoclonal 1D8 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (N-Term) antibodyTIMP3 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 175-211) antibodyTIMP3 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval IHC, FACS, IF Hôte: Lapin Polyclonal unconjugated
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Indications d'application
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))
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Autre désignation
- TIMP3
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Sujet
- The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tightly bound inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knotlike structures. The N terminal region is necessary for inhibitory activity. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved to produce the mature protein. The C terminal regions are divergent and enhance the inhibition selectivity and binding efficiency. Although the TIMP proteins share high homology, following secretion they are localized extracellularly either in soluble form (TIMP1, TIMP2, and TIMP4) or bound to extracellular matrix components (TIMP3).Synonyms: Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3
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Poids moléculaire
- approx. 25 kDa
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ID gène
- 7078
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NCBI Accession
- NP_000353
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UniProt
- P35625
Antigène
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