Transferrin anticorps

N° du produit ABIN125745

Cité dans 1 publication. Cet anticorps anti-Transferrin Monoclonal Souris (Clone PTF-02) (ABIN125745) détecte spécifiquement Transferrin dans WB et ELISA. L’anticorps est réactif avec des échantillons de Porc.

Aperçu rapide pour Transferrin anticorps (ABIN125745)

Antigène: Transferrin (TF)

Reactivité: Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: PTF-02

Détail du produit anti-Transferrin anticorps

Fonction: Anti-Por Transferrin Purified

Aucune reactivité croisée: Cheval, Mouton

Réactivité croisée (Details): Porcine

Attributs du produit: The antibody PTF-02 recognizes porcine serum transferrin, a 77 kDa single polypeptide chain glycoprotein (member of the iron binding family of proteins). It is synthesised in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Porcine transferrin

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Transferrin (ABIN125745)

Trebichavský, Mack?, Viklický, Koukal, Siman: "Monoclonal antibodies against pig transferrin. Blocking and binding activity." dans: Folia microbiologica, Vol. 32, Issue 5, pp. 448-52, (1988) (PubMed).

Détails sur Transferrin

Antigène: Transferrin (TF)

Autre désignation: Transferrin

Sujet: Transferrin,Transferrin is a monomeric glycoprotein of approximately 77 kDa, which serves as an iron-transporter. In normal plasma, transferrin has a concentration of 25-50 µmol / liter, and is usually about one-third saturated with iron, thus providing a large buffering capacity in case of an acute increase in plasma iron levels. Cells take up transferrin-iron complexes (holotransferrin) using transferrin receptor dimers. Upon binding of holotransferrin, the receptor is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with its receptor (CD71) and recycles to the cell surface, where apotransferrin is released upon exposure to normal pH. Internalization of labeled transferrin thus represents an usefull approach to study endocytosis. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions. Iron/transferrin complex is essential in haemoglobin synthesis and for certain types of cell division.,TFQTL1, PRO1557, PRO2086

ID gène: 396996

UniProt: P09571

Pathways: Transition Metal Ion Homeostasis