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Détail du produit
anti-Thymine Dimer anticorps
Aperçu
| Antigène: | Thymine Dimer |
| Clonalité: | Monoclonal (KTM53) |
| Application: | In situ hybridization (ISH) |
| Hôte: | Mouse |
|
6 références disponible |
| Quantité: | |
| Prix: | 460,00 $ (Plus frais de livraison $25 et TVA, Invoice in EUR) |
| Numéro du produit: | ABIN187263 |
| Disponibilité: | Envoi sous 7 à 10 jours ouvrables |
Description du produit » anti-Thymine Dimer anticorps
| Antigène | Thymine Dimer |
| Immunogène | UV-irradiated salmon sperm DNAMouse myeloma (P3/X63-Ag8) x immunized mouse (Balb/c) splenocytes. |
| Clonalité | Monoclonal |
| Format | Purified |
| Isotype | IgG1 »Anticorps secondaires correspondants |
| Clone | KTM53 |
| Hôte | Mouse |
| Specificité | Reacts specifically with thymine dimers produced by UV irradiation in double- or single-stranded DNA. Does not react with (6-4) photo products. |
Applications » anti-Thymine Dimer anticorps
| Application | In situ hybridization (ISH) |
| Indications d'application | In situ hybridization: Use at a 1:40 to 1:80 dilution. The dilution factor depends on the application. Frozen sections of fixed tissue or formalin-fixed, paraffin-embedded sections are recommended. Southern, Northern and Dot Blot: For the detection of thymine dimers in UV-damaged DNA and thymine-dimerized DNA probes used for in situ. (reported to work, but no data is available) Immunocytochemistry: Reported to work by end-user, protocol available. Immunohistochemistry: Published by user. The optimal dilution for a specific application should be determined by the researcher. |
| Buffer | 200 µL of 0.5 mg/mL purified monoclonal antibody in PBS with protein stabilizer and 0.1% sodium azide. Purified by Protein A chromatography. |
| Stock | Store at 4 °C for short term, store at -20 °C for long term. Avoid repeat freeze/thaw cycles. |
| Domaine de recherche | DNA/RNA, Cancer |
| Restrictions | For Research Use only |
Références » anti-Thymine Dimer anticorps
| Références |
Ke, Camouse, Swain et al.: "UV protective effects of DNA repair enzymes and RNA lotion." In: Photochemistry and photobiology
, Vol. 84, Issue 1, pp. 180-4, 2008 (PubMed)
Gambichler, Schlaffke, Tomi et al.: "Tacrolimus ointment neither blocks ultraviolet B nor affects expression of thymine dimers and p53 in human skin." In: Journal of dermatological science , Vol. 50, Issue 2, pp. 115-22, 2008 (PubMed) Ellison, Smith, Gilliam et al.: "Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis." In: The Journal of investigative dermatology , Vol. 128, Issue 10, pp. 2508-17, 2008 (PubMed) Batista, Roos, Kaina et al.: "p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal." In: Molecular cancer research : MCR , Vol. 7, Issue 2, pp. 237-46, 2009 (PubMed) da Silva, Ropke, Miranda et al.: "Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis." In: Cutaneous and ocular toxicology , Vol. 28, Issue 2, pp. 54-60, 2009 (PubMed) Bacqueville, Mavon: "Comparative analysis of solar radiation-induced cellular damage between ex vivo porcine skin organ culture and in vitro reconstructed human epidermis." In: International journal of cosmetic science , 2009 (PubMed) |
Antigènes
