Histone H4 anticorps (ciArg3, N-Term)
Aperçu rapide pour Histone H4 anticorps (ciArg3, N-Term) (ABIN347793)
Antigène
Voir toutes Histone H4 (HISTH4) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- ciArg3, N-Term
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Specificité
- Reacts with human Histone H4 Citrulline at the position 3 (10 kDa)
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Réactivité croisée (Details)
- No cross reaction with free H4 nor with other citrullinated proteins. May cross reacts with other species due to sequence homology.
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Purification
- Antiserum
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Immunogène
- Synthetic peptide derived from Nter region of Human Histone H4, containing Citrulline at position 3
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Isotype
- IgG
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Indications d'application
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA(1:5000 - 1:10000) IHC(1:100 - 1:1000) WB(1:100 - 1:1000) -
Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Must be reconstituted in distilled water.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
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Date de péremption
- 24 months
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- Histone H4 (HISTH4)
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Autre désignation
- Histone H4
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Sujet
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
Antigène
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