Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 (CYP2S1) Kits ELISA

Human Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 (CYP2S1) interaction partners

1. There were 21 genetic variants identified in CYP2S1 in three Chinese populations: Han, Tibetan and Uighur.

2. Biotransformation of (+)-fenchone by Salmonella typhimurium OY1002/2A6 expressing human CYP2A6 and NADPH-P450 reductase.

3. These results suggest that oxaliplatin exerts its inhibitory effects in human CRC cells via upregulation of CYP2S1 expression in a p53-dependent manner.

4. CYP2S1 regulates colorectal cancer growth through associated with prostaglandin E2-mediated activation of beta-catenin signaling.

5. The P450 2S1 may be involved in the reductive detoxication of several of the activated products of carcinogenic aromatic amines and heterocyclic aromatic amines.

6. found that CYP inhibition and siRNA-mediated downregulation of CYP2S1 increased macrophage phagocytosis

7. The reduction in CYP2S1 expression doubled intracellular PGE(2) levels.

8. Data suggest that CYP2S1 is induced in a keratinocyte cell line by exposure to all-trans retinoic acid and ultraviolet B radiation.

9. No association has been found between the CYP2J2 (rs890293, -76G > T) or CYP2S1 (rs34971233, 13106C > T, P466L and rs338583, 13255A > G) gene polymorphisms and respiratory diseases.

10. P450 2S1 can be reduced by NADPH-P450 reductase and suggest normal mixed-function oxidase roles of P450 2S1 to be revealed.

11. identify a novel regulatory cassette that mediates changes in Cyp2s1 expression

12. The presence of a CYP2A-related protein and testosterone metabolism in stellate cell cultures suggest that stellate cells express specific functional isoforms of CYP of which a major form is CYP2S1

13. identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu230Arg, CYP2S1*5A) in exon 5 in Japanese individuals

14. 12 genetic variations, which included the two novel nonsynonymous mutations CYP2S1 S61N (0.3%) and CYP2S1 L230R (0.8%), were identified in 50 Korean subjects

15. Review compares the expression of CYP2S1 mRNA and protein in humans, mice and rats, and critically examines evidence pertaining to CYP2S1 regulation and its catalytic activity.

16. CYP2S1 contributes to the metabolism of environmental carcinogens via a nicotinamide adenine dinucleotide phosphate (NADPH)- independent activity.

Mouse (Murine) Cytochrome P450, Family 2, Subfamily S, Polypeptide 1 (CYP2S1) interaction partners

1. no Cyp2s1 protein was detected in aortae from wild-type mice it was expressed in aortae and macrophage foam cells from ApoE(-/-) mice

2. identify a novel regulatory cassette that mediates changes in Cyp2s1 expression