Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) Kits ELISA

CYP27A1 encodes a member of the cytochrome P450 superfamily of enzymes. De plus, nous expédions CYP27A1 Anticorps (67) et CYP27A1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
CYP27A1 1593 Q02318
CYP27A1 301517 P17178
CYP27A1 104086 Q9DBG1
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 0.055 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Connectez-vous pour afficher 13 to 16 Days
$736.84
Détails
Souris < 0.07 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$810.17
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Rat < 0.07 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Connectez-vous pour afficher 11 to 18 Days
$795.96
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Humain
  96 Tests Connectez-vous pour afficher 2 to 3 Days
$380.00
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CYP27A1 Kits ELISA mieux référencés

  1. Human CYP27A1 Kit ELISA pour Sandwich ELISA - ABIN419215 : Zhao, Li, Wang, Habib, Wei, Sun, Strobel, Jia: Vitamin D serum level is associated with Child-Pugh score and metabolic enzyme imbalances, but not viral load in chronic hepatitis B patients. dans Medicine 2016 (PubMed)

Plus Kits ELISA pour CYP27A1 partenaires d'interaction

Human Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. CYP27A1 SNPs are not associated with vitamin D status and multiple sclerosis.

  2. Vitamin D supplementation can decrease circulating 27HC of breast cancer patients, likely by CYP27A1 inhibition. This suggests a new and additional modality by which vitamin D can inhibit ER+ breast cancer growth, though a larger study is needed for verification.

  3. Whole-exome sequencing assuming recessive inheritance determined his genetic diagnosis to be cerebrotendinous xanthomatosis caused by homozygous mutations (c.410G>A or p.Arg137Gln) in the cytochrome P450 (Montrer CYP Kits ELISA) subfamily 27 A1 (CYP27A1) gene

  4. Three novel mutations in CYP27A1 were found in cerebrotendinous xanthomatosis patients in Chinese families

  5. Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia

  6. Molecular study identified a novel homozygous frameshift mutation in CYP27A1 gene in cerebrotendinous xanthomatosis without cataract

  7. Cerebrotendinous xanthomatosis .. is caused by mutations in the CYP27A1 gene that result in decreased production of chenodeoxycholic acid (CDCA) and elevated levels of cholestanol and bile alcohols. Sequencing of CYP27A1 showed a paternally inherited splice mutation, c.446 + 1G>T, and a maternally inherited nonsense mutation, c.808C>T, predicting p.(Arg270*).

  8. we demonstrated the rare missense variant of CYP27A1 is associated with atopic dermatitis with elevated levels of total serum IgE.

  9. The 32 kb deleted region harbors the CYP2A7 gene and was enriched with enhancer, repressor and insulator sites. The wildtype allele was lost in the polyps of the proband

  10. CYP27A1 is a critical cellular cholesterol sensor in prostate cells and that dysregulation of the CYP27A1/27-hydroxycholesterol (27HC) axis contributes significantly to prostate cancer pathogenesis.

Mouse (Murine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. In het mice, RIF had no effect on plasma lipids composition, CYP27A1 activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression.

  2. CYP46A1 (Montrer CYP46A1 Kits ELISA) is involved in cholestanol removal from the brain and that several factors contribute to the preferential increase in cholestanol in the cerebellum arising from CYP27A1 deficiency.

  3. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein (Montrer Arc Kits ELISA)) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.

  4. overexpression of Cyp27a1 in KCs reduces hepatic inflammation independently of 27HC levels in plasma and liver, further pointing towards KCs as specific target for improving the therapy of NASH.

  5. Data indicate that inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation.

  6. The expression of CYP27A1 modulates the concentrations of active glucocorticoids in both humans and mice and in vitro.

  7. Loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected upregulation of retinal cholesterol biosynthesis. Cyp27a1-/- mice developed retinal lesions with cholesterol deposition beneath the retinal pigment epithelium.

  8. CYP27(-/-) mice exhibited enhanced CCl(4 (Montrer CCL4 Kits ELISA))-induce liver injury, and defective liver regeneration and prolonged steatosis after 70% partial hepatectomy.

  9. Results are consistent with a concentration-dependent flux of 7alpha-hydroxy-4-cholesten-3-one across the blood-brain barrier in cyp27a1(-/-) mice and subsequent formation of cholestanol.

  10. In CYP27A1 ko mice, urinary progesterone concentrations were decreased, 20alpha-DH-progesterone increased, and the progesterone-to-20alpha-DH-progesterone ratio decreased threefold

Cow (Bovine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. isoLG adduction impairs enzyme activity, and support our hypothesis that isoLG modification in the retina is detrimental to CYP27A1 enzyme activity, potentially disrupting cholesterol homeostasis.

  2. Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 (Montrer POR Kits ELISA) CYP27A1 and CYP11A1 (Montrer CYP11A1 Kits ELISA).

  3. Sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elimination of 7-ketocholesterol from the retinal pigment epithelium.

CYP27A1 profil antigène

Antigen Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Gene names and symbols associated with CYP27A1

  • cytochrome P450 family 27 subfamily A member 1 (CYP27A1) anticorps
  • cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1) anticorps
  • cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1) anticorps
  • sterol 26-hydroxylase, mitochondrial (CYP27A1) anticorps
  • cytochrome P450, family 27, subfamily A, polypeptide 1 (cyp27a1) anticorps
  • 1300013A03Rik anticorps
  • CP27 anticorps
  • CTX anticorps
  • Cyp27 anticorps
  • P450C27 anticorps

Protein level used designations for CYP27A1

5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase , 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase , 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase , cholestanetriol 26-monooxygenase , cytochrome P-450C27/25 , cytochrome P450 27 , cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 , sterol 26-hydroxylase, mitochondrial , sterol 27-hydroxylase , vitamin D(3) 25-hydroxylase , cytochrome P-450c27/25 , cholesterol 27 hydroxylase , cytochrome P450, 27 , cytochrome P450, 27a1

GENE ID SPECIES
1593 Homo sapiens
301517 Rattus norvegicus
104086 Mus musculus
610489 Canis lupus familiaris
100126282 Sus scrofa
511960 Bos taurus
100348736 Oryctolagus cuniculus
100381137 Xenopus laevis
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