anti-Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) Anticorps

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP8 Kits (29) et MMP8 Protéines (26) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
MMP8 17394 O70138
MMP8 63849 O88766
MMP8 4317 P22894
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Top anti-MMP8 Anticorps sur

Showing 10 out of 185 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Humain Lapin Inconjugué IHC (p), ELISA, WB Observed bind size: 60KD Anti- MMP8 Picoband antibody,IHC(P) IHC(P): Human Appendicitis Tissue 100 μg 4 to 6 Days
Souris Lapin Inconjugué IHC (p), ELISA, WB Anti- MMP8 Picoband antibody,IHC(P) IHC(P): Mouse Spleen Tissue 100 μg 4 to 6 Days
Humain Lapin Inconjugué IC, IF, IHC, WB Immunofluorescent analysis of MMP8 staining in SW620 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MMP8 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human stomach carcinoma labeled with Rabbit Anti-MMP-8 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3 to 7 Days
Humain Lapin Inconjugué ICC, IF, IP, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using MMP8, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: HCT116 7.5% SDS PAGE antibody diluted at 1:10000 100 μL 3 to 4 Days
Humain Lapin Inconjugué IP, IHC, WB   100 μg 2 to 3 Days
Humain Lapin Inconjugué IHC, ELISA, WB Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MMP-8 Antibody. The picture on the right is treated with the synthesized peptide. Western blot analysis of extracts from NIH-3T3 cells, using MMP-8 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Humain Lapin Inconjugué EIA, IHC (p), WB 0.4 mL 6 to 8 Days
Humain Lapin Inconjugué WB   100 μg 2 to 3 Days
Humain Lapin Inconjugué ELISA, IHC, WB 100 μL 11 to 13 Days

anti-MMP8 Anticorps mieux référencés

  1. Human Polyclonal MMP8 Primary Antibody pour IHC (p), ELISA - ABIN3043882 : Zhong, Wang, Jian: Expression of matrix metalloproteinases-8 and -9 and their tissue inhibitor in the condyles of diabetic rats with mandibular advancement. dans Experimental and therapeutic medicine 2014 (PubMed)
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  2. Human Polyclonal MMP8 Primary Antibody pour IF (p), IHC (p) - ABIN736283 : Zhang, Li, Zhang, Fu, Cui: Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload. dans Acta pharmacologica Sinica 2013 (PubMed)
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  3. Mouse (Murine) Polyclonal MMP8 Primary Antibody pour IHC (p), ELISA - ABIN3043883 : Gao, Tang, He, Liu, Mao, Ji, Lin, Wu: Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats. dans Frontiers in pharmacology 2015 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal MMP8 Primary Antibody pour IHC (p), ELISA - ABIN545721 : Nagase, Woessner: Matrix metalloproteinases. dans The Journal of biological chemistry 1999 (PubMed)
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  5. Human Monoclonal MMP8 Primary Antibody pour CyTOF, FACS - ABIN4899598 : Arechavaleta-Velasco, Marciano, Díaz-Cueto, Parry: Matrix metalloproteinase-8 is expressed in human chorion during labor. dans American journal of obstetrics and gynecology 2004 (PubMed)

  6. Human Polyclonal MMP8 Primary Antibody pour IHC, IHC (p) - ABIN4335077 : Ong, Elkington, Brilha, Ugarte-Gil, Tome-Esteban, Tezera, Pabisiak, Moores, Sathyamoorthy, Patel, Gilman, Porter, Friedland: Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. dans PLoS pathogens 2015 (PubMed)

  7. Human Polyclonal MMP8 Primary Antibody pour IP, IHC - ABIN223233 : Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. dans The Journal of thoracic and cardiovascular surgery 2007 (PubMed)

  8. Human Polyclonal MMP8 Primary Antibody pour IHC - ABIN6711843 : Takeuchi, Kimura, Okamoto, Aoyagi, Miyamoto, Kaji, Takenaka, Okamura, Sato, Kato, Okahisa, Takayama: A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors. dans Journal of gastroenterology 2012 (PubMed)

Plus d’anticorps contre MMP8 partenaires d’interaction

Mouse (Murine) Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8.

  2. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3

  3. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression.

  4. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia.

  5. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.

  6. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.

  7. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta.

  8. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I levels.

  9. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha activity, which may explain neuroinflammation in septic mouse brain.

  10. MMP-13 prevails over MMP-8 in collagen degradation in atheromata.

  11. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10, N-cadherin, and beta-catenin-mediated pathway and plays an important role in neointima formation.

  12. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo.

  13. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions.

  14. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia.

  15. Mmp-8 has a protective role in arthritis

  16. MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases. Rather, MMP-8 is important for normal rates of neutrophil apoptosis and hence regulates cell clearance.

  17. MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit ventilator-induced lung injury.

  18. MMP-8 potently reduces the accumulation of neutrophils and macrophages in the lungs of mice with lipopolysaccharide- and bleomycin-induced acute lung injury.

  19. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR.

  20. In vitro, fewer MMP-8(-/-) PMNs migrated thru 3D cross-linked collagen gels than WT PMNs.This was likely a result of pericollagenase activity of MMP-8, as WT PMNs expressing MMP-8 could not migrate effectively thru collagen resistant to the collagenase.

Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. Two polymorphisms of MMP-8 and MMP-27 were significantly associated with recurrent pregnancy loss (RPL) risk, both individually and in combination. Therefore, these two polymorphisms are potential biomarkers for RPL susceptibility.

  2. No significant interactions were noted between the MMP3, MMP8 and TIMP2 genes with ACLR susceptibility despite the known biological interactions between the proteins.

  3. data showed that polymorphisms of MMP8 and MMP9 may be associated with breast cancer risk in the Chinese Han population.

  4. rs1939012 may play a potential role of gene regulation and/or epistasis in a complex etiology of vertigo.

  5. High-serum MMP-8 levels are associated with systemic inflammation and adverse outcome in colorectal cancer.

  6. Data demonstrate significantly higher serum concentrations of inflammatory biomarkers MMP-8, MPO and TIMP-1 in acute ischemic stroke cases.

  7. A significant association of rs1799750 (MMP-1) and rs11225395 (MMP-8) polymorphism on early implant loss was demonstrated (P

  8. Peri-implant sulcular fluid levels of MMP-8 and MMP-9 are significantly higher among waterpipe smokers compared with never-smokers with peri-implantitis.

  9. MMP-8 and TIMP-1 in serum, but not MMP-9, identified colorectal cancer patients with bad prognosis

  10. MMP-1 and MMP-8 gene polymorphisms have a role in promoting the increase and remodeling of the collagen III and V in posterior tibial tendinopathy

  11. The meta-analysis results showed a remarkable association between rs11225394 in MMP-8 gene and an increased risk of osteonecrosis of the femoral head and a significant association between MMP-8 rs2012390 and the decreased risk of osteonecrosis of the femoral head.

  12. Results suggest that MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan.

  13. Low MMP8 level is associated with gastric cancer.

  14. Five single nucleotide polymorphisms including rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 of MMP-8 gene were genotyped in a Chinese Han population. It was found rs3740938 of MMP-8 was associated with an increased risk of ankylosing spondylitis under the dominant model and additive model after adjustment for gender and age by performing logistic regression analysis.

  15. Data show that polymorphism in the promoter region of matrix metallopeptidase 8 (MMP-8) (-799C/T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) were not significantly associated with risk of pterygium.pterygium.

  16. Persistent oral human papillomavirus infection was associated with a low salivary MMP-8 concentration indicating eventually a failure in oral anti-inflammatory defence.

  17. Reduced expression of types I and III collagen and TIMP-1 as well as the increased expression of MMP-1 and MMP-8 in the anterior vaginal wall tissues play important roles in the onset of pelvic organ prolapse.

  18. Genetic polymorphism in S100A9-S100A12-S100A8 locus affects serum and plasma MMP-8 and shows a suggestive association with the risk of cardiovascular diseases.

  19. Our study demonstrated that the MMP-8 C-799T is associated with the risk of developing severe preeclampsia during pregnancy. However, the MMP-8 C + 17G polymorphism might not be a risk factor for susceptibility to preeclampsia.

  20. Our findings suggest that the polymorphisms at MMP-8 -799C/T, Val436Ala and Lys460Thr may not play a major role in determining the personal susceptibility to childhood acute lymphoblastic leukemia in Taiwan.

MMP8 profil antigène

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP8

  • matrix metallopeptidase 8 (MMP8) anticorps
  • matrix metallopeptidase 8 (Mmp8) anticorps
  • neutrophil collagenase (LOC100339790) anticorps
  • BB138268 anticorps
  • CLG1 anticorps
  • HNC anticorps
  • MMP-8 anticorps
  • MMP8 anticorps
  • PMNL-CL anticorps

Protein level used designations for MMP8

matrix metallopeptidase 8 (neutrophil collagenase) , matrix metalloproteinase 8 , MMP-8 , collagenase 2 , collagenase-2 , matrix metalloproteinase-8 , neutrophil collagenase , neutrophil collagenease , PMNL collagenase , matrix metalloproteinase 8 (neutrophil collagenase)

740516 Pan troglodytes
17394 Mus musculus
63849 Rattus norvegicus
4317 Homo sapiens
100724670 Cavia porcellus
100339790 Oryctolagus cuniculus
Fournisseurs de qualité sélectionnés pour anti-MMP8 (MMP8) Anticorps
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