Matrix Metallopeptidase 8 (Neutrophil Collagenase) Protéines (MMP8)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. De plus, nous expédions MMP8 Anticorps (197) et MMP8 Kits (120) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
MMP8 17394 O70138
MMP8 63849 O88766
MMP8 4317 P22894
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Top MMP8 Protéines sur anticorps-enligne.fr

Showing 10 out of 29 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
Human Cells Humain His tag 10 μg Connectez-vous pour afficher 14 to 16 Days
$250.80
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,370.21
Détails
CHO Cells Souris His tag 10 μg Connectez-vous pour afficher 14 to 16 Days
$250.80
Détails
Human Cells Souris Inconjugué 10 μg Connectez-vous pour afficher 14 to 16 Days
$250.80
Détails
HEK-293 Cells Humain Inconjugué   10 μg Connectez-vous pour afficher 10 to 12 Days
$222.28
Détails
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$720.00
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 13 to 16 Days
$400.00
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$230.67
Détails
Human Cells Humain His tag   10 μg Connectez-vous pour afficher 15 to 16 Days
$325.00
Détails

MMP8 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) , ,

Rat (Rattus) ,
,
Human , , , ,
,

Plus protéines pour Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) partenaires d'interaction

Mouse (Murine) Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8.

  2. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3

  3. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression.

  4. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia.

  5. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.

  6. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.

  7. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta.

  8. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I levels.

  9. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha activity, which may explain neuroinflammation in septic mouse brain.

  10. MMP-13 prevails over MMP-8 in collagen degradation in atheromata.

  11. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10, N-cadherin, and beta-catenin-mediated pathway and plays an important role in neointima formation.

  12. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo.

  13. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions.

  14. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia.

  15. Mmp-8 has a protective role in arthritis

  16. MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases. Rather, MMP-8 is important for normal rates of neutrophil apoptosis and hence regulates cell clearance.

  17. MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit ventilator-induced lung injury.

  18. MMP-8 potently reduces the accumulation of neutrophils and macrophages in the lungs of mice with lipopolysaccharide- and bleomycin-induced acute lung injury.

  19. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR.

  20. In vitro, fewer MMP-8(-/-) PMNs migrated thru 3D cross-linked collagen gels than WT PMNs.This was likely a result of pericollagenase activity of MMP-8, as WT PMNs expressing MMP-8 could not migrate effectively thru collagen resistant to the collagenase.

Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) (MMP8) interaction partners

  1. MMP-8 and TIMP-1 in serum, but not MMP-9, identified colorectal cancer patients with bad prognosis

  2. MMP-1 and MMP-8 gene polymorphisms have a role in promoting the increase and remodeling of the collagen III and V in posterior tibial tendinopathy

  3. The meta-analysis results showed a remarkable association between rs11225394 in MMP-8 gene and an increased risk of osteonecrosis of the femoral head and a significant association between MMP-8 rs2012390 and the decreased risk of osteonecrosis of the femoral head.

  4. Results suggest that MMP8 C-799T, Val436Ala and Lys460Thr may only play an indirect role in determining personal cancer susceptibility for bladder cancer in Taiwan.

  5. Low MMP8 level is associated with gastric cancer.

  6. Five single nucleotide polymorphisms including rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 of MMP-8 gene were genotyped in a Chinese Han population. It was found rs3740938 of MMP-8 was associated with an increased risk of ankylosing spondylitis under the dominant model and additive model after adjustment for gender and age by performing logistic regression analysis.

  7. Data show that polymorphism in the promoter region of matrix metallopeptidase 8 (MMP-8) (-799C/T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) were not significantly associated with risk of pterygium.pterygium.

  8. Persistent oral human papillomavirus infection was associated with a low salivary MMP-8 concentration indicating eventually a failure in oral anti-inflammatory defence.

  9. Reduced expression of types I and III collagen and TIMP-1 as well as the increased expression of MMP-1 and MMP-8 in the anterior vaginal wall tissues play important roles in the onset of pelvic organ prolapse.

  10. Genetic polymorphism in S100A9-S100A12-S100A8 locus affects serum and plasma MMP-8 and shows a suggestive association with the risk of cardiovascular diseases.

  11. Our study demonstrated that the MMP-8 C-799T is associated with the risk of developing severe preeclampsia during pregnancy. However, the MMP-8 C + 17G polymorphism might not be a risk factor for susceptibility to preeclampsia.

  12. Our findings suggest that the polymorphisms at MMP-8 -799C/T, Val436Ala and Lys460Thr may not play a major role in determining the personal susceptibility to childhood acute lymphoblastic leukemia in Taiwan.

  13. Reduction in serum levels of MMP8 predicted complete remission in type 2 diabetes mellitus patients following bariatric surgery.

  14. MMP8 -799C/T, Val436Ala and Lys460Thr polymorphisms may only play an indirect role in determining personal cancer susceptibility to breast cancer in Taiwan.

  15. Our findings suggest that the polymorphisms at MMP-8 C-799T or Val436Ala may not play a major role in mediating personal risk of oral cancer; however, the detailed mechanisms require further investigation.

  16. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8.

  17. among Chinese males, MMP-3 rs650108 and MMP-8 rs2012390 decrease alcohol-induced ONFH risk and MMP-8 rs11225394 increases it.

  18. Data show that individuals with MMP-8 -799TT genotype and intermediate HIV disease stage are at higher risk for the advancement of HIV disease. MMP-8 polymorphism indicated a trend of elevated risk for the modulation of HIV-associated neurocognitive disorder (HAND) severity. MMP-8 -799TT genotype may facilitate the risk for the development of HAND with tobacco and alcohol usage.

  19. The serum levels of IL-8, MIP-1 alpha, MIP-1 beta, MMP-8, Resistin, FLRG, and BCAM were significantly higher in breast cancer patients, but LAP and TSH-beta levels were lower.

  20. Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization.

Profil protéine MMP8

Profil protéine

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP8

  • matrix metallopeptidase 8 (MMP8)
  • matrix metallopeptidase 8 (Mmp8)
  • neutrophil collagenase (LOC100339790)
  • BB138268 Protéine
  • CLG1 Protéine
  • HNC Protéine
  • MMP-8 Protéine
  • MMP8 Protéine
  • PMNL-CL Protéine

Protein level used designations for MMP8

matrix metallopeptidase 8 (neutrophil collagenase) , matrix metalloproteinase 8 , MMP-8 , collagenase 2 , collagenase-2 , matrix metalloproteinase-8 , neutrophil collagenase , neutrophil collagenease , PMNL collagenase , matrix metalloproteinase 8 (neutrophil collagenase)

GENE ID SPECIES
740516 Pan troglodytes
17394 Mus musculus
63849 Rattus norvegicus
4317 Homo sapiens
100724670 Cavia porcellus
100339790 Oryctolagus cuniculus
Fournisseurs de qualité sélectionnés pour MMP8 Protéines (MMP8)
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