Apamin

N° du produit ABIN1540024

Détail du produit

Antigène: Apamin

Application: Blocking Reagent (BR)

Fonction: Apamin is a SK channel inhibitor

Séquence: Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2Disulfide bonds between Cys1-Cys11 and Cys3-Cys15

Information d'application

Restrictions: For Research Use only

Stockage

Détail du antigène

Antigène: Apamin

Synonymes: GB18161 Accessory Reagents, apamin protein Accessory Reagents, Apamin Accessory Reagents

Sujet: Apamin is a neurotoxin that was originally isolated from Apis mellifera. Apamin binds to and inhibits the SK channels (small conductance Ca2+-activated K+ channels) in the brain and spinal cord. It inhibits three subtypes of SK channels (SK1, SK2, and SK3) with different affinity. Apamin most likely acts as a pore blocker, although residues both inside and outside of the pore region of the SK channels participate in0 apamin binding. The SK channels are present in a wide range of excitable and non-excitable cells, including cells in the central nervous system, intestinal myocytes, endothelial cells, and hepatocytes.

Poids moléculaire: 2027.34 Da

Numéro CAS: 24345-16-2