Kaliotoxin-1

N° du produit ABIN1540091

Aperçu rapide pour Kaliotoxin-1 (ABIN1540091)

Antigène: Kaliotoxin-1

Application: Blocking Reagent (BR)

Détail du produit

Fonction: Kaliotoxin-1 is a BK channel inhibitor

Séquence: Gly-Val-Glu-Ile-Asn-Val-Lys-Cys8-Ser-Gly-Ser-Pro-Gln-Cys14-Leu-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OHDisulfid e bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35

Information d'application

Restrictions: For Research Use only

Stockage

Détail du antigène

Antigène: Kaliotoxin-1

Sujet: Kaliotoxin-1 has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 is a potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). This toxin also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Kaliotoxin-1 induces atransient period of fast flickering in the channel openings, followed by an almost complete blockage of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.

Poids moléculaire: 4150.37 Da