ALK Produits
(Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
Catégories
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).[provided by RefSeq, Jan 2011].
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Catégories ALK en vedette
ALK Anticorps
High quality antibodies with extensive validation data.
ALK recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (7)
N° du produit
ABIN7442819
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (3)
N° du produit
ABIN7529465
Quantité
20 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7368872
Quantité
50 μg
Fiche technique
Fiche technique
ALK recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7282100
Quantité
200 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
N° du produit
ABIN7272289
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7415581
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ALK
: "Anaplastic lymphoma kinase immunohistochemistry in lung adenocarcinomas: Evaluation of performance of standard manual method using D5F3 antibody." dans: Indian journal of cancer, Vol. 54, Issue 1, pp. 209-213, (2018) (PubMed).: "Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma." dans: Oncology letters, Vol. 15, Issue 6, pp. 9317-9326, (2018) (PubMed).
: "Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement." dans: Oncotarget, Vol. 8, Issue 49, pp. 86066-86081, (2017) (PubMed).
: "Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 116-25, (2016) (PubMed).
: "A novel, highly sensitive ALK antibody 1A4 facilitates effective screening for ALK rearrangements in lung adenocarcinomas by standard immunohistochemistry." dans: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 10, Issue 4, pp. 713-6, (2015) (PubMed).
: "Inflammatory myofibroblastic tumour of the bladder in children: A review." dans: Journal of pediatric urology, (2015) (PubMed).
: "Extraordinary response to crizotinib in a woman with squamous cell lung cancer after two courses of failed chemotherapy." dans: BMC pulmonary medicine, Vol. 14, pp. 83, (2014) (PubMed).
: "Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms." dans: Human molecular genetics, Vol. 19, Issue 18, pp. 3544-56, (2010) (PubMed).
: "Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1." dans: Blood, Vol. 89, Issue 4, pp. 1394-404, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à ALK
anaplastic lymphoma kinase (Alk), anaplastic lymphoma receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (ALK), ALK receptor tyrosine kinase (Alk), ALK, CD246, NBLST3, TcrzProtein level used designations for ALK
- ALK tyrosine kinase receptor
- anaplastic lymphoma kinase (Ki-1)
- CD246 antigen
- mutant anaplastic lymphoma kinase
- anaplastic lymphoma receptor tyrosine kinase
- anaplastic lymphoma kinase
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