BIN3 anticorps

N° du produit ABIN1043741

Détail du produit anti-BIN3 anticorps

Antigène: BIN3 (Bridging Integrator 3 (BIN3))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BIN3 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Anti-BIN3 was purified from clarified mouse ascetic fluid by Protein A chromatography followed by extensive dialysis against the buffer stated above. BIN3 antibody is specific for human BIN3 protein. A BLAST analysis was used to suggest cross-reactivity with BIN3 from human and mouse sources based on 100% homology with the immunizing sequence. Cross-reactivity with BIN3 from other sources has not been determined.

Attributs du produit: BIN-3 encodes an evolutionarily conserved and ubiquitously expressed member of the BAR superfamily of curved membrane and GTPase-binding proteins implicated in signal transduction and vesicular trafficking. In humans, Bin3 maps to chromosome 8p21.3, a region widely implicated in cancer suppression that is often deleted in non-Hodgkin’s lymphomas and various epithelial tumors. Study in mouse suggests that homozygous inactivation of Bin3 causes cataracts and an increased susceptibility to lymphomas during aging.

Stérilité: Sterile filtered

Immunogène: Anti-BIN3 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with a GST tagged full legnth human BIN3 protein followed by hybridoma development.
Immunogen Type: RecombinantProtein

Clone: 3A4

Isotype: IgG1

Information d'application

Indications d'application: Anti-BIN3 antibody has been tested for use in ELISA, Western Blot, and IP. Specific conditions for reactivity should be optimized by the end user.

Commentaires:

Gene Name: BIN3

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Date de péremption: 12 months

Références pour anticorps anti-BIN3 (ABIN1043741)

Routhier, Burn, Abbaszade, Summers, Albright, Prendergast: "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p." dans: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21670-7, (2001) (PubMed).

Détails sur BIN3

Antigène: BIN3 (Bridging Integrator 3 (BIN3))

Autre désignation: BIN3 (BIN3 Produits)

Synonymes: anticorps 1700015F07Rik, anticorps bridging integrator 3, anticorps BIN3, anticorps Bin3

Sujet: BIN-3 encodes an evolutionarily conserved and ubiquitously expressed member of the BAR superfamily of curved membrane and GTPase-binding proteins implicated in signal transduction and vesicular trafficking. In humans, Bin3 maps to chromosome 8p21.3, a region widely implicated in cancer suppression that is often deleted in non–Hodgkin’s lymphomas and various epithelial tumors. Study in mouse suggests that homozygous inactivation of Bin3 causes cataracts and an increased susceptibility to lymphomas during aging.
Synonyms: Bridging integrator 3, BIN-3, BIN 3, BIN3 antibody, anti-BIN3 antibody

ID gène: 55909

NCBI Accession: NP_061158

UniProt: Q9NQY0