Pellino 1 anticorps (C-Term)

N° du produit ABIN1077389

Détail du produit anti-Pellino 1 anticorps

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Pellino 1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: Rabbit polyclonal Pellino 1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Pellino 1.

Isotype: IgG

Information d'application

Indications d'application: Pellino 1 antibody can be used for detection of Pellino 1 by Western blot at 1 - 2 μg/mL.

Commentaires:

(CT) Pellino E3 ubiquitin protein ligase 1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Stock: 4 °C

Stockage commentaire: Pellino 1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Date de péremption: 12 months

Détails sur Pellino 1

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Autre désignation: PELI1 (PELI1 Produits)

Synonymes: anticorps 2810468L03Rik, anticorps A930031K15Rik, anticorps AA409794, anticorps AI586297, anticorps D11Ertd676e, anticorps peli1, anticorps peli1.L, anticorps pellino1, anticorps xpellino1, anticorps wu:fd12d01, anticorps zgc:153297, anticorps pellino E3 ubiquitin protein ligase 1, anticorps pellino 1, anticorps pellino E3 ubiquitin protein ligase 1 S homeolog, anticorps pellino E3 ubiquitin protein ligase 1b, anticorps PELI1, anticorps Peli1, anticorps peli1.S, anticorps peli1b

Sujet: The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-kB. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-epsilon and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.
Synonyms: Pellino E3 ubiquitin protein ligase 1, PELI1, pellino1, pellino-1

Poids moléculaire: 46 kDa

ID gène: 57162

NCBI Accession: NP_065702

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades