PAX5 anticorps (AA 235-382)

N° du produit ABIN1098104

L’anticorps Souris Monoclonal anti-PAX5 a été validé pour ELISA et IHC. Il convient pour détecter PAX5 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour PAX5 anticorps (AA 235-382) (ABIN1098104)

Antigène: PAX5 (Paired Box 5 (PAX5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX5 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: 7D3

Détail du produit anti-PAX5 anticorps

Épitope: AA 235-382

Fonction: PAX5 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PAX5 (ABIN1098104)

OBrien, Morin, Ouellette, Robichaud: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." dans: Cancer research, Vol. 71, Issue 24, pp. 7345-50, (2011) (PubMed).

Nasr, Rosenthal, Syrbu: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." dans: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, (2009) (PubMed).

Détails sur PAX5

Antigène: PAX5 (Paired Box 5 (PAX5))

Autre désignation: PAX5

Sujet: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Poids moléculaire: 45 kDa

UniProt: Q02548