Prosaposin anticorps (AA 325-524)

N° du produit ABIN1098150

Cet anticorps anti-Prosaposin est un anticorps Souris Monoclonal détectant Prosaposin dans IHC, ELISA, ICC et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Prosaposin anticorps (AA 325-524) (ABIN1098150)

Antigène: Prosaposin (PSAP)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Prosaposin est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4D5F4

Détail du produit anti-Prosaposin anticorps

Épitope: AA 325-524

Fonction: PSAP Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Prosaposin (ABIN1098150)

Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: "The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." dans: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).

Hu, Delorme, Liu, Liu, Velasco-Gonzalez, Garai, Pullikuth, Koochekpour: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." dans: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).

Détails sur Prosaposin

Antigène: Prosaposin (PSAP)

Autre désignation: PSAP

Sujet: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 58.1 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity