ACIN1 anticorps (N-Term)

N° du produit ABIN1105223

L’anticorps anti-ACIN1 Monoclonal Souris est utilisé pour la détection de ACIN1 dans des échantillons de Humain. Il a été validé pour WB et IP.

Aperçu rapide pour ACIN1 anticorps (N-Term) (ABIN1105223)

Antigène: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ACIN1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: 3H8

Détail du produit anti-ACIN1 anticorps

Épitope: AA 1-523, N-Term

Specificité: This antibody reacts withAcinusL.

Réactivité croisée (Details): Species reactivity (tested):Human.
Does not react with mouse (WR19L, NIH3T3) or hamster (CHO).

Purification: Protein A agarose beads

Immunogène: GST-human AcinusL fusion protein corresponding to N-terminal amino acids (1~523 a.a.)

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur ACIN1

Antigène: ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))

Autre désignation: Acinus / ACIN1

Sujet: Chromatin condensation and nuclear fragmentation (CCNF) are hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase-activated DNase (CAD/DFF40) and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (Apoptotic Chromatin Condensation Inducer in the Nucleus). The 220 kDa Acinus protein is cleaved by caspase-3 and an additional unknown protease to generate a 17 kDa peptide that which causes chromatin condensation in vitro when added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS, and AcinusS'. Acinus is ubiquitously expressed.Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670

Poids moléculaire: 220 kDa

ID gène: 22985

NCBI Accession: NP_001158286

UniProt: Q9UKV3