Asialoglycoprotein Receptor 1 anticorps (FITC)

N° du produit ABIN1105448

L’anticorps Souris Monoclonal anti-Asialoglycoprotein Receptor 1 a été validé pour WB, IF, EIA et IHC (fro). Il convient pour détecter Asialoglycoprotein Receptor 1 dans des échantillons de Humain et Rat.

Aperçu rapide pour Asialoglycoprotein Receptor 1 anticorps (FITC) (ABIN1105448)

Antigène: Asialoglycoprotein Receptor 1 (ASGR1)

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Asialoglycoprotein Receptor 1 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 8D7

Détail du produit anti-Asialoglycoprotein Receptor 1 anticorps (FITC)

Réactivité croisée (Details): Species reactivity (tested):Human, Rat.

Purification: Protein G

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur Asialoglycoprotein Receptor 1

Antigène: Asialoglycoprotein Receptor 1 (ASGR1)

Autre désignation: ASGR1

Sujet: The asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways.Synonyms: ASGP-R 1, ASGPR 1, Asialoglycoprotein receptor 1, Hepatic lectin H1

UniProt: P02706

Pathways: Thyroid Hormone Synthesis