CD180 anticorps (FITC)

N° du produit ABIN1105959

Cet anticorps anti-CD180 est un anticorps Rat Monoclonal détectant CD180 dans FACS. Adapté pour Souris.

Aperçu rapide pour CD180 anticorps (FITC) (ABIN1105959)

Antigène: CD180 (CD180 Molecule (CD180))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD180 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: RP-14

Détail du produit anti-CD180 anticorps (FITC)

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein G

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

Date de péremption: 6 months

Détails sur CD180

Antigène: CD180 (CD180 Molecule (CD180))

Autre désignation: CD180 / RP105

Sujet: Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.Synonyms: LY64, Lymphocyte antigen 64, Radioprotective 105 kDa protein

ID gène: 10090

UniProt: Q62192

Pathways: Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades