PROCR anticorps (FITC)

N° du produit ABIN1106044

Détail du produit anti-PROCR anticorps (FITC)

Antigène: PROCR (Protein C Receptor, Endothelial (PROCR))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PROCR est conjugé à/à la FITC

Application: Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func)

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G

Clone: RCR-252

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 1 % bovine serum

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur PROCR

Antigène: PROCR (Protein C Receptor, Endothelial (PROCR))

Autre désignation: CD201 / EPCR (PROCR Produits)

Synonymes: anticorps PROCR, anticorps CCCA, anticorps CCD41, anticorps EPCR, anticorps AI325044, anticorps Ccca, anticorps Ccd41, anticorps Epcr, anticorps protein C receptor, anticorps protein C receptor, endothelial, anticorps PROCR, anticorps Procr

Sujet: Endothelial protein C receptor (EPCR) is a highly glycosylated type I transmembrane protein of 221-amino-acids. These amino acids comprise an extracellular domain, a 25-aa transmembrane domain, and a short (3 aa) intracytoplasmic sequence coding for an ~46 kDa protein. Deglycosylation will reduce the protein mass to 25 kDa. EPCR is expressed strongly on the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. EPCR is the receptor for protein C, a key player in the anticoagulation pathway. The protein C anticoagulant pathway serves as a major system for controling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. The essential components of the pathway include thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. The pathway is initiated when thrombin binds to thrombomodulin on the surface of endothelium. EPCR augments protein C activation by binding protein C and presenting it to the thrombin-thrombomodulin activation complex. Activated protein C (aPC) retains its ability to bind EPCR, and this complex appears to be involved in some of the cellular signaling mechanisms that down-regulate inflammatory cytokine formation (TNF, IL-6). EPCR is shed from the vasculature by inflammatory mediators and thrombin. EPCR binds to activated neutrophils in a process that involves proteinase 3 and Mac-1. Furthermore, EPCR can undergo translocation from the plasma membrane to the nucleus. EPCR can be cleaved to release a soluble form (sEPCR) in the circulation. This sEPCR is detected as a single species of 43 kDa, resulting from shedding of membrane EPCR by the action of a metalloprotease, which is stimulated by thrombin and by some inflammatory mediators. Soluble EPCR binds PC and aPC with similar affinity, but its binding to aPC inhibits the anticoagulant activity of aPC by blocking its binding to phospholipids and by abrogating its ability to inactivate factor Va. sEPCR can be detected in plasma. In normal persons, sEPCR is present in levels of 83.6 +/- 17.2 ng/mL. Elevated levels of sEPCR are positively correlated to a higher risk for thrombosis. Furthermore, a haplotype (A3 allele) has been linked to elevated levels of sEPCR (264 +/-174 ng/mL).Synonyms: APC receptor, Activated protein C receptor, Endothelial cell protein C receptor, Endothelial protein C receptor, PROCR

UniProt: Q9UNN8