F11R anticorps

N° du produit ABIN1106263

Cet anticorps Rat Monoclonal détecte spécifiquement F11R dans IHC (fro). Il présente une réactivité envers Souris.

Aperçu rapide pour F11R anticorps (ABIN1106263)

Antigène: F11R (F11 Receptor (F11R))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp F11R est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 27-09-14

Détail du produit anti-F11R anticorps

Purification: This antibody was purified from hybridoma (clone 27-9) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell P3X with Wister rat lymphocyte immunized with E14.5 mouse fetal liver cells.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2 containing no preservative

Agent conservateur: Without preservative

Détails sur F11R

Antigène: F11R (F11 Receptor (F11R))

Autre désignation: CD321 / JAM1

Sujet: Junctional adhesion molecules (JAMs) are member of the immunoglobulin superfamily. JAMs play an important role in many cellular processes such as tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is a 37 kDa protein also called JAM-1 or F11R. JAM-A is expressed on endothelial cells, epithelial cells, and also hematopoietic cells such as neutrophils, platelets, monocytes, lymphocyte and erythrocyte. Extracellular domain of JAM-A participates in homophilic interaction stabilizing endothelial or epithelial cell-cell junctions particularly around tight junctions. In addition, JAM-A is important in leukocyte transmigration. Not only homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the β2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to mediate leukocyte transmigration.Synonyms: F11R, JAM-A, JCAM, Junctional adhesion molecule 1, Junctional adhesion molecule A, PAM1, Platelet F11 receptor, Platelet adhesion molecule 1

Pathways: Cell-Cell Junction Organization