CD43 anticorps (FITC)

N° du produit ABIN1106375

L’anticorps Souris Monoclonal anti-CD43 a été validé pour FACS et IF. Il convient pour détecter CD43 dans des échantillons de Humain.

Aperçu rapide pour CD43 anticorps (FITC) (ABIN1106375)

Antigène: CD43 (SPN) (Sialophorin (SPN))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD43 est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: MT1

Détail du produit anti-CD43 anticorps (FITC)

Specificité: Clone MT1, specific for CD43, produces mouse IgG1 immunoglobulins reactive with a 95-115 kDa highly sialated glycoprotein. Clone MT1 antibody is used to identify B cell lines and myeloma cells. It may be used in the diagnosis of chronic lymphocytic leukemias (CLL), as an alternative to CD5. The antigen detected by MT1 is the only marker expressed on neoplasms of the very early precursor cells. In immunohistochemistry it reacts with T cells, macrophages, myeloid cells and B cells (weak). It is used for the typing of lymphomas in paraffin sections [3-5].

Purification: Affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Détails sur CD43

Antigène: CD43 (SPN) (Sialophorin (SPN))

Autre désignation: CD43 / Leukosialin

Sujet: CD43 antigen is expressed on all T cells, NK cells, myeloid cells and monocytes as well as on CD5 positive mature B cells. It is also present on all immature hematopoietic cells in the bone marrow [1]. The antigen is deficient in patients with Wiskott-Aldrich syndrome. A soluble form of CD43 is present in human serum [2]. CD43 may function as an adhesion molecule via interaction with CD54 although this has not been definitely established. It may also inhibit leucocyte interactions with other cells [6]. The antigen is involved in the activation of T-cells, B cells, NK cells and monocytes [5]. The membrane proximal portion of the cytoplasmic domain mediates an association with the cytoskeleton [1].Synonyms: Galactoglycoprotein, Leukocyte sialoglycoprotein, SPN, Sialophorin

ID gène: 6693

NCBI Accession: NP_001025459

UniProt: P16150

Pathways: Regulation of Leukocyte Mediated Immunity