COL2 anticorps

N° du produit ABIN1106744

L’anticorps Souris Monoclonal anti-COL2 a été validé pour IHC (p), IHC (fro), Func et EIA. Il convient pour détecter COL2 dans des échantillons de Humain, Souris, Rat, Poulet et Boeuf (Vache).

Aperçu rapide pour COL2 anticorps (ABIN1106744)

Antigène: COL2 (Collagen, Type II (COL2))

Reactivité: Humain, Souris, Rat, Poulet, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp COL2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: M2139

Détail du produit anti-COL2 anticorps

Specificité: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1 (cat.no. AM26375PU-N), binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat, bovine, chicken

Purification: Protein G

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur COL2

Antigène: COL2 (Collagen, Type II (COL2))

Autre désignation: Collagen Type II

Sujet: Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II

ID gène: 1280

NCBI Accession: NP_001835

UniProt: P02458