COL2 anticorps

N° du produit ABIN1106744

Détail du produit anti-COL2 anticorps

Antigène: COL2 (Collagen, Type II (COL2))

Reactivité: Humain, Souris, Rat, Poulet, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp COL2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Specificité: The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. It has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1 (cat.no. AM26375PU-N), binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat, bovine, chicken

Purification: Protein G

Clone: M2139

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur COL2

Antigène: COL2 (Collagen, Type II (COL2))

Autre désignation: Collagen Type II (COL2 Produits)

Synonymes: anticorps PT, anticorps RPRGL2, anticorps THPH1, anticorps Cf-2, anticorps Cf2, anticorps FII, anticorps thrombin, anticorps prothrombin, anticorps CAP18, anticorps Cnlp, anticorps Cramp, anticorps FALL39, anticorps MCLP, anticorps coagulation factor II, thrombin, anticorps coagulation factor II, anticorps cathelicidin antimicrobial peptide, anticorps Cuticle collagen 2, anticorps collagen type II alpha 1 chain, anticorps F2, anticorps Camp, anticorps col-2, anticorps COL2A1

Sujet: Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA).Synonyms: COL2, Collagen II

ID gène: 1280

NCBI Accession: NP_001835

UniProt: P02458