RCAS1 anticorps

N° du produit ABIN1107048

Cet anticorps anti-RCAS1 est un anticorps Souris Monoclonal détectant RCAS1 dans IHC (p) et FACS. Adapté pour Humain.

Aperçu rapide pour RCAS1 anticorps (ABIN1107048)

Antigène: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RCAS1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 22-01-01

Détail du produit anti-RCAS1 anticorps

Specificité: This antibody recognizes RCAS1.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein-L Sepharose

Immunogène: Human uterine cervical adenocarcinoma cell

Isotype: IgM

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 100 μg IgG in 100 μLvolukme of PBS containing 50 % glycerol and 0.5 M NaCl, pH 7.2 No preservative is contained.

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur RCAS1

Antigène: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Autre désignation: EBAG9 / RCAS1

Sujet: RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1.Synonyms: Cancer-associated surface antigen RCAS1, EB9, Estrogen receptor-binding fragment-associated gene 9 protein, PDAF, Receptor-binding cancer antigen expressed on SiSo cells

ID gène: 9166

NCBI Accession: NP_004206

UniProt: O00559