PI3 anticorps (C-Term)

N° du produit ABIN1107081

Cet anticorps anti-PI3 est un anticorps Souris Monoclonal détectant PI3 dans WB, IHC (p) et EIA. Adapté pour Humain.

Aperçu rapide pour PI3 anticorps (C-Term) (ABIN1107081)

Antigène: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PI3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: TRAB2F

Détail du produit anti-PI3 anticorps

Épitope: C-Term

Specificité: TRAB2F is an Elafin/SKALP specific antibody which shows strong reaction with fully processed Elafin/SKALP (C-terminal 57 aa) and a weaker reaction with human native full-length Elafin/SKALP. The antibody can be used for purification of human native full-length Elafin/SKALP.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur PI3

Antigène: PI3 (Peptidase Inhibitor 3, Skin-Derived (PI3))

Autre désignation: Elafin / PI3

Sujet: Elafin is an epithelial proteinase inhibitor also known under various other names such as Skin-derived Anti leukoproteinase (SKALP) and Elastase-Specific Inhibitor (ESI). Elafin belongs to the Trappin gene family and was given the systematic name Trappin-2. The Trappin family is defined by a N-terminal transglutaminase substrate domain and a C-terminal four disulphide core. Trappins have been suggested to play a role in the regulation of inflammation and in protection against tissue damage in stratified epithelia. Elafin is an inhibitor of leukocyte elastase and proteinase-3 and is a substrate for transglutaminases. The protein is constitutively expressed in various epithelia including hair follicles, oesophagus, vagina and oral cavity. Elafin is not present in normal human skin but is strongly induced during inflammation as in psoriasis and wound healing. Antibodies to Elafin can be used to evaluate the effects of treatment of psoriasis since its expression is significantly correlated with clinical scores. Antibodies to Elafin have also been succesfully used to study differentiation in squamous cell carcinoma of the head-and-neck region, oesophagus and skin. It is also shown that Elafin possesses antimicrobial activity against gram-positive and gram-negative bacteria.Synonyms: ESI, Elastase-specific inhibitor, PI-3, Peptidase inhibitor 3, Protease inhibitor WAP3, SKALP, Skin-derived antileukoproteinase, WAP four-disulfide core domain protein 14, WAP3, WFDC14

ID gène: 5266

NCBI Accession: NP_002629

UniProt: P19957