Methylglyoxal Modified Proteins anticorps

N° du produit ABIN1108230

Cet anticorps anti-Methylglyoxal Modified Proteins Monoclonal Souris (Clone MGO-1) (ABIN1108230) détecte spécifiquement Methylglyoxal Modified Proteins dans IHC (p), WB et EIA. L’anticorps est réactif avec des échantillons de Différentes espèces.

Aperçu rapide pour Methylglyoxal Modified Proteins anticorps (ABIN1108230)

Antigène: Methylglyoxal Modified Proteins

Reactivité: Différentes espèces

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: MGO-1

Détail du produit

Réactivité croisée (Details): Species reactivity (tested):Human. Multispecies cross reactant.

Purification: Protein G

Immunogène: MGO-modified KLH

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détail du antigène

Antigène: Methylglyoxal Modified Proteins

Sujet: Methylglyoxal (MGO) is an endogenous product of glucose metabolism. Increased production and accumulation of methylglyoxal (MGO), as well as increased modification of proteins by glycoxidation, are hallmarks of aging and diabetes. MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells. A number of studies have shown that MGO levels are significantly elevated in patients with Type 2 Diabetes and correlates well with fasting plasma glucose and hemoglobin A1c (HbA1c) levels. Moreover, increased formation of the MGO is implicated in renal dysfunction and is known to be involved in the development of DN (diabetic nephropathy).