Myeloperoxidase anticorps (Biotin)

N° du produit ABIN1108345

Cet anticorps Souris Monoclonal détecte spécifiquement Myeloperoxidase dans IHC (fro) et EIA. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour Myeloperoxidase anticorps (Biotin) (ABIN1108345)

Antigène: Myeloperoxidase (MPO)

Reactivité: Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Myeloperoxidase est conjugé à/à la Biotin

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: 8F4

Détail du produit anti-Myeloperoxidase anticorps (Biotin)

Réactivité croisée (Details): Species reactivity (tested):Mouse, rat

Purification: Protein G

Immunogène: Purified mouse MPO from WEHI-3 cells

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur Myeloperoxidase

Antigène: Myeloperoxidase (MPO)

Autre désignation: Myeloperoxidase

Sujet: MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150 kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an diagnostic marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice.Synonyms: MPO

UniProt: P11247

Pathways: Chromatin Binding