PLGF anticorps (N-Term)

N° du produit ABIN1108665

Cet anticorps anti-PLGF est un anticorps Lapin Polyclonal détectant PLGF dans WB, IHC (p) et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PLGF anticorps (N-Term) (ABIN1108665)

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLGF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-PLGF anticorps

Épitope: N-Term

Specificité: This antibody detects Placenta growth factor / PGF (N-term). No cross reactivity with other proteins.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat.

Purification: Immunogen affinity purified

Immunogène: Synthetic peptide corresponding to a sequence mapping near the N-terminal of human PLGF .Remarks: Sequence is different from the related rat sequence by two different amino acids.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: 1.2 % sodium acetate or neutral PBS. If 0.5 mL of PBS is used, the antibody concentration will be 100 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur PLGF

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Autre désignation: Placenta Growth Factor / PGF

Sujet: Placental growth factor (PGF, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro. PGF is located on chromosome 14 and has been conserved in evolution. It belongs to the family of vascular endothelial growth factors (VEGFs) and binds to the flt-1 VEGF receptor. PLGF-2, which is a PLGF isoform, binds neuropilin-1 and 2 in a heparin-dependent manner. PGF regulates inter-and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes. Moreover, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1.Synonyms: PGFL, PLGF, PlGF

ID gène: 5228

NCBI Accession: NP_002623

UniProt: P49763

Pathways: VEGFR1 Specific Signals