This antibody recognizes the surfactant protein B (SP-B). It rescognizes under nonreducing conditions the most prominent forms of SP-B of 8 kDa and 22 kDa, corresponding to SP-B dimers.
Réactivité croisée (Details)
Species reactivity (tested):Human, pig
Purification
Protein A
Immunogène
Pig SP-B from pig lungs which has been reconstituted in micelles of lysophosphatidylcholine
anticorps PSP-B, anticorps SFTB3, anticorps SFTP3, anticorps SMDP1, anticorps SP-B, anticorps AI562151, anticorps SF-B, anticorps Sftp-3, anticorps Sftp3, anticorps Sp-b, anticorps SFTPB, anticorps sftpb, anticorps xSP-B, anticorps surfactant protein B, anticorps surfactant associated protein B, anticorps surfactant, pulmonary-associated protein B L homeolog, anticorps SFTPB, anticorps Sftpb, anticorps sftpb.L
Sujet
There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-B is synthesized by the alveolar type II epithelial cells as a 40-42 kD precursor that is subsequently proteolytically processed to 7.8-8 kD. SP-B enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-B is essential for air-breathing in mammals and is therefore largely conserved. SP-B can interact with both phospholipid head groups and fatty chains and is particularly active in enhancing surface active behaviour in endogenous and exogenous lung surfactants. Even low SP-B contents had measurable effects in increasing the adsorption, dynamic surface tension lowering, and/or film respreading of DPPC, mixed synthetic lipids, and column-purified lung surfactant phospholipids. Deficiency of SP-B and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS).Synonyms: 18 kDa pulmonary-surfactant protein, Pulmonary surfactant-associated protein B, Pulmonary surfactant-associated proteolipid SPL(Phe), SFTP3, SP-B, Surfactant protein B