Siglec H anticorps

N° du produit ABIN1109009

Détail du produit anti-Siglec H anticorps

Antigène: Siglec H

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Siglec H est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein G

Clone: 440c

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur Siglec H

Antigène: Siglec H

Autre désignation: Siglec-H (Siglec H Produits)

Synonymes: anticorps 6430529G09Rik, anticorps Siglec-H, anticorps sialic acid binding Ig-like lectin H, anticorps Siglech

Sujet: Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo.

UniProt: Q3Y597