SKP2 anticorps (N-Term)
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- Antigène Voir toutes SKP2 Anticorps
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SKP2 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects SKP2 / FBXL1 (N-term). No cross reactivity with other proteins.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat.
- Purification
- Immunogen affinity purified
- Immunogène
- synthetic peptide corresponding to a sequence at the N-terminal of human SKP2 .Remarks: Sequence is different from the related rat and mouse sequence by three amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SKP2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Reconstitution
- 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Buffer
- 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Agent conservateur
- Sodium azide, Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
- Autre désignation
- SKP2 / FBXL1 (SKP2 Produits)
- Synonymes
- anticorps FBXL1, anticorps FBL1, anticorps FLB1, anticorps p45, anticorps RGD1562456, anticorps S-phase kinase-associated protein 2 (p45), anticorps S-phase kinase associated protein 2, anticorps Skp2, anticorps SKP2
- Sujet
- The F box protein Skp2 (S-phase kinase-associated protein 2) is oncogenic, and its frequent amplification and overexpression correlate with the grade of malignancy of certain tumors. Skp2 controls p300-p53 signaling pathways in cancer cells, making it a potential molecular target for cancer therapy. This gene positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. This study provides evidence of a role for an F-box protein in oncogenesis and establishes SKP2 as a protooncogene causally involved in the pathogenesis of lymphomas.Synonyms: Cyclin-A/CDK2-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2
- ID gène
- 6502
- NCBI Accession
- NP_005974
- UniProt
- Q13309
- Pathways
- Mitotic G1-G1/S Phases
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