TREM2 anticorps

N° du produit ABIN1109326

Cet anticorps Rat Monoclonal détecte spécifiquement TREM2 dans IP et EIA. Il présente une réactivité envers Souris.

Aperçu rapide pour TREM2 anticorps (ABIN1109326)

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM2 est non-conjugé

Application: Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Clone: 6-00E-009

Détail du produit anti-TREM2 anticorps

Specificité: The monoclonal antibody 6E9 recognizes membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2).

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Purified

Immunogène: Mouse recombinant TREM-2 protein

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 02 % Sodium Azide, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur TREM2

Antigène: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Autre désignation: TREM2

Sujet: TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.Synonyms: TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2

ID gène: 83433

NCBI Accession: NP_112544

UniProt: Q99NH8