TRIM13 anticorps (Middle Region)

N° du produit ABIN1109332

Cet anticorps Lapin Polyclonal détecte spécifiquement TRIM13 dans WB et IHC (p). Il présente une réactivité envers Humain, Souris, Rat et Boeuf (Vache).

Aperçu rapide pour TRIM13 anticorps (Middle Region) (ABIN1109332)

Antigène: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TRIM13 anticorps

Épitope: Middle Region

Séquence: DTLETSKRKS LQLLTKDSDK VKEFFEKLQH TLDQKKNEIL SDFETMKLAV

Réactivité croisée (Details): Species reactivity (expected):Rat, Mouse, BovineSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: The immunogen for anti-TRIIM13 antibody: synthetic peptide directed towards the middle region of human TRIM13

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur TRIM13

Antigène: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Autre désignation: TRIM13 / RNF77

Sujet: TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.Synonyms: B-cell chronic lymphocytic leukemia tumor suppressor Leu5, LEU5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RFP2, RING finger protein 77, Tripartite motif-containing protein 13

ID gène: 10206

NCBI Accession: NP_005789