TRIM13 anticorps (Middle Region)

N° du produit ABIN1109332

Détail du produit anti-TRIM13 anticorps

Antigène: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM13 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: DTLETSKRKS LQLLTKDSDK VKEFFEKLQH TLDQKKNEIL SDFETMKLAV

Réactivité croisée (Details): Species reactivity (expected):Rat, Mouse, BovineSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: The immunogen for anti-TRIIM13 antibody: synthetic peptide directed towards the middle region of human TRIM13

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur TRIM13

Antigène: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Autre désignation: TRIM13 / RNF77 (TRIM13 Produits)

Synonymes: anticorps TRIM13, anticorps RFP2, anticorps CAR, anticorps DLEU5, anticorps LEU5, anticorps RNF77, anticorps 3110001L12Rik, anticorps Rfp2, anticorps tripartite motif containing 13, anticorps ret finger protein 2, anticorps tripartite motif-containing 13, anticorps TRIM13, anticorps LOC100338599, anticorps Trim13

Sujet: TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.Synonyms: B-cell chronic lymphocytic leukemia tumor suppressor Leu5, LEU5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RFP2, RING finger protein 77, Tripartite motif-containing protein 13

ID gène: 10206

NCBI Accession: NP_005789