TSFM anticorps (N-Term)

N° du produit ABIN1109361

Détail du produit anti-TSFM anticorps

Antigène: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSFM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Séquence: KQAEIWLHKE AQKEGWSKAA KLQGRKTKEG LIGLLQEGNT TVLVEVNCET

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Dog, African clawed frog, Bovine, ZebrafishSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: The immunogen for anti-TSFM antibody: synthetic peptide directed towards the N terminal of human TSFM.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur TSFM

Antigène: TSFM (Ts Translation Elongation Factor, Mitochondrial (TSFM))

Autre désignation: TSFM (TSFM Produits)

Synonymes: anticorps EF-Ts, anticorps EF-TsMt, anticorps EFTS, anticorps zgc:158429, anticorps EFTSMT, anticorps 2310050B20Rik, anticorps 9430024O13Rik, anticorps EF-TS, anticorps EF-Tsmt, anticorps 2A3-2, anticorps Elongation factor Ts, mitochondrial, anticorps Ts translation elongation factor, mitochondrial, anticorps Ts translation elongation factor, mitochondrial L homeolog, anticorps pco103788, anticorps tsfm, anticorps tsfm.L, anticorps TSFM, anticorps Tsfm

Sujet: The TSFM gene encodes a protein that is expressed in all tissues, with the highest levels of expression in skeletal muscle, liver, and kidney. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3). Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexesSynonyms: EF-Ts, EF-TsMt, Elongation factor Ts mitochondrial

ID gène: 10102

NCBI Accession: NP_005717