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KRT20 anticorps

KRT20 Reactivité: Humain, Porc WB, IHC (fro) Hôte: Souris Monoclonal KS20-3 unconjugated
N° du produit ABIN111168
  • Antigène Voir toutes KRT20 Anticorps
    KRT20 (Keratin 20 (KRT20))
    Reactivité
    • 91
    • 29
    • 27
    • 9
    • 6
    • 2
    • 2
    • 1
    • 1
    Humain, Porc
    Hôte
    • 62
    • 30
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 52
    • 45
    Monoclonal
    Conjugué
    • 63
    • 12
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KRT20 est non-conjugé
    Application
    • 68
    • 46
    • 25
    • 15
    • 14
    • 12
    • 11
    • 9
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    IT-Ks 20.3 represents an excellent marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin. Very sensitive detection of intestestinal and gastric foveolar epithelium, urothelial umbrella cells, Merkel cells of epidermis as well as tumors originating therefrom (e.g. primary and metastatic colorectal carcinoma). Adenocarcinomas of breast, lung, endometrium and ovary (non-mucinous) as well as neuroendocrine tumors of the lung are essentially negative. Polypeptide recognized: protein IT (keratin K20, Mr 46 000, formerly also designated cytokeratin 20).
    Purification
    Protein A affinity chromatography
    Immunogène
    Electrophoretically purified keratin K20 from human intestinal mucosa.
    Clone
    KS20-3
    Isotype
    IgG1
    Top Product
    Discover our top product KRT20 Anticorps primaire
  • Indications d'application
    Immunohistochemistry on frozen sections: 1: 10. Western Blot. Incubation Time: 1 h at RT or over night at 2-8C.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in 1 mL dist. water
    Buffer
    Contains 0.09 % sodium azide, 0.5 % BSA in PBS buffer, pH 7.4
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Antigène
    KRT20 (Keratin 20 (KRT20))
    Autre désignation
    Cytokeratin 20 (KRT20 Produits)
    Synonymes
    anticorps KRT20, anticorps CD20, anticorps CK-20, anticorps CK20, anticorps K20, anticorps KRT21, anticorps Krt21, anticorps 9030623C06Rik, anticorps keratin 20, anticorps KRT20, anticorps Krt20
    Sujet
    Cytokeratin 20 is a type I keratin which is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel-cells. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Their genes are clustered in a region of chromosome 17q12-q21. Cytokeratin 20 is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. It is also expressed in adenocarcinomas of the colon, stomach, pancreas and the bile system and is present in mucinous ovarian tumors, transitional-cell and Merkel-cell carcinomas. Notably, the squamous cell carcinomas and adenocarcinomas of the breast, lung, and endometrium, non-mucinous tumors of the ovary, and small cell carcinomas lack cytokeratin 20.Synonyms: CK20, Cytokeratin 20, K20, KRT20, Keratin type I cytoskeletal 20, Keratin-20, Protein IT
    ID gène
    54474
    NCBI Accession
    NP_061883
    UniProt
    P35900
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