Fibronectin anticorps

N° du produit ABIN112024

Cet anticorps Souris Monoclonal détecte spécifiquement Fibronectin dans IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour Fibronectin anticorps (ABIN112024)

Antigène: Fibronectin

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibronectin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: EP5

Détail du produit anti-Fibronectin anticorps

Specificité: Recognizes Fibronectin specifically in connective tissues and vessels. No reactivity with the soluble dimeric form of Fibronectin (plasma Fibronectin), but highly reactive with matrix Fibronectin. Animal biodistribution experiments have shown that after intravenous administration, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Protein A chromatography

Immunogène: Native human fibronectin (matrix)

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry on frozen and paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS, pH 7.2, 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C foor one month or (in aliquots) at -20 °C for longer.

Détails sur Fibronectin

Antigène: Fibronectin

Sujet: Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).Synonyms: CIG, Cold-insoluble globulin, FN1

ID gène: 2335

NCBI Accession: NP_002017

UniProt: P02751