Fibronectin anticorps
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- Antigène Voir toutes Fibronectin Anticorps
- Fibronectin
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Reactivité
- Humain, Souris
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Fibronectin est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- Recognizes Fibronectin specifically in connective tissues and vessels. No reactivity with the soluble dimeric form of Fibronectin (plasma Fibronectin), but highly reactive with matrix Fibronectin. Animal biodistribution experiments have shown that after intravenous administration, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indicating that this antibody can be used to target tumor vessels specifically in vivo.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse.
- Purification
- Protein A chromatography
- Immunogène
- Native human fibronectin (matrix)
- Clone
- EP5
- Isotype
- IgG1
- Top Product
- Discover our top product Fibronectin Anticorps primaire
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- Indications d'application
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Immunohistochemistry on frozen and paraffin embedded sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- PBS, pH 7.2, 0.09 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C foor one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Fibronectin
- Abstract
- Fibronectin Produits
- Synonymes
- anticorps FN, anticorps cig, anticorps fibronectin, anticorps finc, anticorps lets, anticorps msf, anticorps CIG, anticorps ED-B, anticorps FINC, anticorps FNZ, anticorps GFND, anticorps GFND2, anticorps LETS, anticorps MSF, anticorps E330027I09, anticorps Fn, anticorps Fn-1, anticorps FIBNEC, anticorps fn-1, anticorps fibronectin 1, anticorps FN1, anticorps fn1, anticorps Fn1
- Sujet
- Fibronectin is a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. They occur as dimers of two 250 kDa subunits. They have binding domains for bacterial proteins, collagens, heparin-like molecules and fibrin. Cellular fibronectin is widely distributed in the stroma of malignant tumours. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins).Synonyms: CIG, Cold-insoluble globulin, FN1
- ID gène
- 2335
- NCBI Accession
- NP_002017
- UniProt
- P02751
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