Myeloperoxidase anticorps

N° du produit ABIN113005

Cet anticorps Lapin Polyclonal détecte spécifiquement Myeloperoxidase dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Myeloperoxidase anticorps (ABIN113005)

Antigène: Myeloperoxidase (MPO)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Myeloperoxidase est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Myeloperoxidase anticorps

Purification: Ammonium sulfate precipitation and DEAE-Sephacel ion exchange chromatography.

Immunogène: Neutrophil Myeloperoxidase

Information d'application

Indications d'application: ELISA (>1: 4,000) and western blotting (1: 4,000 dilution gives a strong reaction to 0.3 and0.6 g antigen).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.07 mg/mL (OD280 nm, E0.1% = 1.4).

Buffer: PBS, pH 7.4, with 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Myeloperoxidase

Antigène: Myeloperoxidase (MPO)

Autre désignation: Myeloperoxidase

Sujet: Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Synonyms: MPO

ID gène: 9606

UniProt: P05164

Pathways: Chromatin Binding