Ceruloplasmin anticorps

N° du produit ABIN113276

L’anticorps Mouton Polyclonal anti-Ceruloplasmin a été validé pour EIA et IHC (fro). Il convient pour détecter Ceruloplasmin dans des échantillons de Humain.

Aperçu rapide pour Ceruloplasmin anticorps (ABIN113276)

Antigène: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Reactivité: Humain

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp Ceruloplasmin est non-conjugé

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Ceruloplasmin anticorps

Specificité: Recognizes Ceruloplasmin. This antibody shows minimal reactivity with related serum proteins.

Purification: Ammonium Sulphate Fractionation

Immunogène: Native human Ceruloplasmin

Information d'application

Indications d'application: Immunohistochemistry on Frozen Sections (1/20-1/200). ELISA (Has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 μ/wellcoated).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS, pH 7.2 contaioning 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Ceruloplasmin

Antigène: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Autre désignation: Ceruloplasmin

Sujet: Ceruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132 kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95 % of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson's disease, where levels are greatly reduced. Ceruloplasmin is extremely labile in plasma and rapidly degrades to 115 kDa and 19 kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of ceruloplasmin.Synonyms: CP, Ferroxidase

ID gène: 1356

NCBI Accession: NP_000087

UniProt: P00450

Pathways: Transition Metal Ion Homeostasis