PSMA anticorps

N° du produit ABIN114548

Détail du produit anti-PSMA anticorps

Antigène: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PSMA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects PSMA expressed LNCap cell lines. Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein G.

Immunogène: Crude membrane protein preparation from pooled prostate malignant carcinoma from China.

Clone: Y-PSMA1

Isotype: IgG2b

Information d'application

Indications d'application: ELISA. Western blot. Immunofluorescence. Immunohistochemistry on Formalin-Fixed Paraffin Embedded and Frozen Tissue Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with double distillated water to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS, pH 7.0 without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store lyophilized (preferably in a desiccator) at -20 °C and in aliquots at -80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time, it does not show decline in activity after two weeks at 4 °C.

Détails sur PSMA

Antigène: PSMA (FOLH1) (Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 (FOLH1))

Autre désignation: PSMA / FOLH1 (FOLH1 Produits)

Synonymes: anticorps FGCP, anticorps FOLH, anticorps GCP2, anticorps GCPII, anticorps NAALAD1, anticorps NAALAdase, anticorps PSM, anticorps PSMA, anticorps mGCP, anticorps mopsm, anticorps Naalad, anticorps putative N-acetylated-alpha-linked acidic dipeptidase, anticorps folate hydrolase 1B, anticorps folate hydrolase 1, anticorps folate hydrolase (prostate-specific membrane antigen) 1, anticorps LOC451185, anticorps FOLH1B, anticorps FOLH1, anticorps Folh1

Sujet: PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.Synonyms: FOLH, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, GCP2, Glutamate carboxypeptidase 2, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, NAALAD1, NAALAdase, PSM, Prostate-specific membrane antigen, Pteroylpoly-gamma-glutamate carboxypeptidase

ID gène: 2346

NCBI Accession: NP_001014986

UniProt: Q04609