Thymidine Phosphorylase anticorps

N° du produit ABIN114826

Cet anticorps Souris Monoclonal détecte spécifiquement Thymidine Phosphorylase dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Thymidine Phosphorylase anticorps (ABIN114826)

Antigène: Thymidine Phosphorylase (TYMP)

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thymidine Phosphorylase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: P-GF-44C

Détail du produit anti-Thymidine Phosphorylase anticorps

Specificité: This antibody is specific to a 55 kDa protein known as Platelet-Derived Endothelial Growth Factor (PD-ECGF), similar to thymidine phosphorylase (TP). Cellular localization: Cytoplasmic, Nuclear.

Purification: Purified

Immunogène: A recombinant full length human thymidine phophorylase (TP/PD-ECGF) protein.

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of1/25-1/75 in an ABC method (30 minutes at room temperature). Western blotting: 1/50-1/100. Recommended Positive Control: Breast carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Thymidine Phosphorylase

Antigène: Thymidine Phosphorylase (TYMP)

Sujet: Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites. High levels of TP/PD-ECGF are observed in cancer patients. High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Synonyms: ECGF1, Gliostatin, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase

ID gène: 1890

NCBI Accession: NP_001107227

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2