Thymidine Phosphorylase anticorps

N° du produit ABIN114827

Détail du produit anti-Thymidine Phosphorylase anticorps

Antigène: Thymidine Phosphorylase (TYMP)

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thymidine Phosphorylase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody is specific to a 55 kDa protein known as Platelet-Derived Endothelial Growth Factor (PD-ECGF), similar to thymidine phosphorylase (TP). Cellular localization: Cytoplasmic, Nuclear.

Purification: Purified

Immunogène: A recombinant full length human thymidine phophorylase (TP/PD-ECGF) protein.

Clone: P-GF-44C

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of1/25-1/75 in an ABC method (30 minutes at room temperature). Western blotting: 1/50-1/100. Recommended Positive Control: Breast carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Thymidine Phosphorylase

Antigène: Thymidine Phosphorylase (TYMP)

Abstract: TYMP Produits

Synonymes: anticorps ECGF, anticorps ECGF1, anticorps MEDPS1, anticorps MNGIE, anticorps MTDPS1, anticorps PDECGF, anticorps TP, anticorps hPD-ECGF, anticorps 2900072D10Rik, anticorps Ecgf1, anticorps PD-ECGF, anticorps Pdgfec, anticorps typh, anticorps thymidine phosphorylase, anticorps thymidine phosphorylase DeoA, anticorps AMP phosphorylase, anticorps Thymidine phosphorylase, anticorps TYMP, anticorps Tymp, anticorps deoA, anticorps Dd586_0614, anticorps Kvar_4413, anticorps NMAG_RS19330, anticorps Snov_1187, anticorps Fbal_2856, anticorps Ftrac_2071, anticorps Intca_1216, anticorps ARCVE_RS10415, anticorps Sphch_4174, anticorps Sinme_3461, anticorps METOK_RS06355, anticorps Mesop_1831, anticorps typh

Sujet: Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites. High levels of TP/PD-ECGF are observed in cancer patients. High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Synonyms: ECGF1, Gliostatin, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase

ID gène: 1890

NCBI Accession: NP_001107227

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2