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Ezrin anticorps (AA 362-585)

Name: Ezrin anticorps (AA 362-585)
SKU: ABIN115201
Price: 1536.15 EUR
Availability: InStock

EZR Reactivité: Humain, Souris, Rat, Boeuf (Vache), Hamster, Kangourou WB, IP, IHC (p) Hôte: Souris Monoclonal 3C12 unconjugated

Formalin fixed paraffin embedded human lung stained with Ezrin antibody. (Ezrin anticorps (AA 362-585))

IHC

1 image

(2 références)

N° du produit ABIN115201

Fiche de données

Antigène Voir toutes Ezrin (EZR) Anticorps

Ezrin (EZR)
Épitope
29

16

12

11

9

9

8

8

5

5

5

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 362-585
Reactivité
154

82

74

8

7

7

6

5

3

3

3

1

1

1

1
Humain, Souris, Rat, Boeuf (Vache), Hamster, Kangourou
Hôte
140

13

3

2
Souris
Anticorps secondaires appropriés
Clonalité
137

20
Monoclonal
Conjugué
89

8

8

7

7

7

7

7

4

3

2

2

2

2

2

1
Cet anticorp Ezrin est non-conjugé
Application
117

54

27

16

14

14

13

13

10

8

3

2

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité

This antibody reacts with a protein of 81 kDa.
Cellular Localization: Cell membrane

Purification

Purified

Immunogène

BALB/C mice were immunized with a recombinant fragment of human ezrin corresponding to amino acid 362-585.

Clone

3C12

Isotype

IgG1

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anti-Ezrin (EZR) (AA 455-586) antibody
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Indications d'application

Immunoprecipitation. Western blot: 1: 100-750. Immunohistochemistry on paraffin embedded sections: dilute 1: 50-1: 100 in an ABC method(30 minutes at room temperature). Recommended positive control: Lung.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions

For Research Use only
Format

Liquid

Conseil sur la manipulation

Avoid repeated freezing and thawing.

Stock

4 °C/-20 °C

Stockage commentaire

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Hatano, Akiyama, Tamura, Hosogi, Marunaka, Caplan, Ueno, Tsukita, Asano: "Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice." dans: Hepatology (Baltimore, Md.), Vol. 61, Issue 5, pp. 1660-71, (2015) (PubMed).

Fonseca, Freund, Bornhäuser, Corbeil: "Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network." dans: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31661-71, (2010) (PubMed).
Antigène

Ezrin (EZR)

Autre désignation

Ezrin (EZR Produits)

Synonymes

anticorps CVIL, anticorps CVL, anticorps VIL2, anticorps ezr, anticorps vil2, anticorps wu:fc05c03, anticorps wu:fj31d06, anticorps cvil, anticorps cvl, anticorps Vil2, anticorps AW146364, anticorps R75297, anticorps p81, anticorps ezr.S, anticorps ezrin, anticorps ezrin b, anticorps ezrin L homeolog, anticorps EZR, anticorps ezrb, anticorps ezr, anticorps Ezr, anticorps ezr.L

Sujet

Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.Synonyms: Cytovillin, EZR, VIL2, Villin-2, p81

ID gène

7430

NCBI Accession

NP_001104547

UniProt

P15311

Pathways

Maintenance of Protein Location