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ADIPOQ anticorps (N-Term)

ADIPOQ Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN115498
  • Antigène Voir toutes ADIPOQ Anticorps
    ADIPOQ (Adiponectin (ADIPOQ))
    Épitope
    • 18
    • 11
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 152
    • 63
    • 41
    • 17
    • 11
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 141
    • 67
    • 6
    • 3
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 149
    • 70
    Polyclonal
    Conjugué
    • 131
    • 34
    • 16
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ADIPOQ est non-conjugé
    Application
    • 129
    • 101
    • 70
    • 35
    • 30
    • 27
    • 26
    • 21
    • 20
    • 12
    • 10
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MRGSHHHHHH GSGHDQETTT QGPGVLLPLP KGACTGWMAG IPGHPGHNGA PGRDGRDGTP GEKGEKGDPG LIGPKGDIGE TGVPGAEGPR GFPGIQGRKG EPGEGAYVYR SAFSVGLETY VTIPNMPIRF TKIFYNQQNH YDGSTGKFHC NIPGLYYFAY HITVYMKDVK VSLFKKDKAM LFTYDQYQEN NVDQASGSVL LHLEVGDQVW LQVYGEGERN GLYADNDNDS TFTGFLLYHD TN Remarks: Source of Antigen: E.Coli
    Specificité
    The antibody was raised in rabbits by immunization with the recombinant Adiponectin.
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography.
    Immunogène
    The immunization antigen (26.4 kDa) is a protein containing 242 AA of recombinant Human Adiponectin. N-Terminal His-tag, 12 extra AA (highlighted).
    Top Product
    Discover our top product ADIPOQ Anticorps primaire
  • Indications d'application
    Western Blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore with 0.1 mL of deionized water and let and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
    Buffer
    0.05 M phosphate buffer, 0.5 M NaCl, pH 7.2, None
    Agent conservateur
    Without preservative
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.
    Date de péremption
    6 months
  • Badakhshi, Marnitz, Scherer, Budach, Haisch: "[Adenoid cystic carcinoma of the oropharynx. Brachytherapy for the treatment of local recurrences]" dans: HNO, Vol. 56, Issue 3, pp. 328-31, (2008) (PubMed).

  • Antigène
    ADIPOQ (Adiponectin (ADIPOQ))
    Autre désignation
    Adiponectin (ADIPOQ Produits)
    Synonymes
    anticorps ADP, anticorps DCAF9, anticorps 6720489L24Rik, anticorps 9330209L04Rik, anticorps Adp, anticorps Mamdc1, anticorps RNSVSP4U, anticorps SVSIV1, anticorps Svp4, anticorps ACDC, anticorps ACRP30, anticorps ADIPQTL1, anticorps ADPN, anticorps APM-1, anticorps APM1, anticorps GBP28, anticorps apM-1, anticorps 30kDa, anticorps APN, anticorps Acdc, anticorps Acrp30, anticorps Ad, anticorps adipo, anticorps apM1, anticorps ADN, anticorps acrpl, anticorps adipo-b, anticorps adipoql, anticorps zgc:153584, anticorps adipoq, anticorps WD and tetratricopeptide repeats 1, anticorps MAM domain containing glycosylphosphatidylinositol anchor 2, anticorps seminal vesicle secretory protein 4, anticorps adiponectin, C1Q and collagen domain containing, anticorps adiponectin, C1Q and collagen domain containing, b, anticorps adiponectin, C1Q and collagen domain containing L homeolog, anticorps WDTC1, anticorps Mdga2, anticorps Svs4, anticorps ADIPOQ, anticorps Adipoq, anticorps adipoqb, anticorps adipoq.L
    Sujet
    Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily, it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01 % of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned, AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoproteincholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.Synonyms: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
    ID gène
    9370
    NCBI Accession
    NP_001171271
    UniProt
    Q15848
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