Endoglin anticorps (AA 22-586)

N° du produit ABIN115697

L’anticorps Lapin Polyclonal anti-Endoglin a été validé pour WB, FACS et EIA. Il convient pour détecter Endoglin dans des échantillons de Humain.

Aperçu rapide pour Endoglin anticorps (AA 22-586) (ABIN115697)

Antigène: Endoglin (ENG)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Endoglin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Détail du produit anti-Endoglin anticorps

Épitope: AA 22-586

Purification: Protein A Chromatography

Immunogène: Recombinant Human soluble CD105/Endoglin (aa. 22 (Glu) to 586 (Leu)) derived from Insect Cells

Information d'application

Indications d'application: Elisa (1-15 μg/mL). Western blot (1-2 μg/mL with the appropriate secondary reagents). FACS analysis and cell sorting (2-5 μg/mL together with the appropriate secondaryreagents).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL

Buffer: PBS, pH 7.4 without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: CD105 / Endoglin

Sujet: Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1

ID gène: 9606

UniProt: P17813