Endoglin anticorps (AA 26-581)

N° du produit ABIN115702

Cet anticorps Lapin Polyclonal détecte spécifiquement Endoglin dans WB, FACS et EIA. Il présente une réactivité envers Souris.

Aperçu rapide pour Endoglin anticorps (AA 26-581) (ABIN115702)

Antigène: Endoglin (ENG)

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Endoglin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Détail du produit anti-Endoglin anticorps

Épitope: AA 26-581

Purification: Protein A Chromatography (+his tag depleted)

Immunogène: Highly pure recombinant Mouse soluble CD105 produced in Insect cells. The recombinant soluble CD105 consists of amino acid 26(Glu) to 581 (Gly) and is fused to a C-terminal His-tag (6xHis).

Information d'application

Indications d'application: ELISA (1-15 μg/mL). Western blot (1-2 μg/mL). Flow Cytometry (3-20 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with sterile water to a concentration of 0.1-1.0 mg/mL

Buffer: PBS, pH 7.2 without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store the at -20 °C.

Détails sur Endoglin

Antigène: Endoglin (ENG)

Autre désignation: CD105 / Endoglin

Sujet: Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart evelopment. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular isorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1

ID gène: 10090

UniProt: Q63961