SIRT6 anticorps

N° du produit ABIN1169069

L’anticorps anti-SIRT6 Monoclonal Souris est utilisé pour la détection de SIRT6 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour SIRT6 anticorps (ABIN1169069)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: S6R82-2

Détail du produit anti-SIRT6 anticorps

Fonction: anti-Sirtuin 6 (human), mAb (S6R82-2)

Specificité: Recognizes human sirtuin 6. Detects a band of ~47 kDa by Western blot.

Attributs du produit: Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47 kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human sirtuin 6.

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Agent conservateur: Without preservative

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: Sirtuin 6

Sujet:

Alternate Names/Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6, Mono-ADP-ribosyltransferase Sirtuin 6, SIR2-like Protein 6, SIR2L6

Product Description: Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

UniProt: Q8N6T7