BTLA anticorps

N° du produit ABIN1169098

Détail du produit anti-BTLA anticorps

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp BTLA est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Specificité: Recognizes human BTLA.

Réactivité croisée: Humain

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

niveau d'endotoxine: <0.001EU/μg purified protein.

Immunogène: Ectodomain of human BTLA fused to human IgG Fc.

Clone: 6F4

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-BTLA (ABIN1169098)

Cheung, Oborne, Steinberg, Macauley, Fukuyama, Sanjo, DSouza, Norris, Pfeffer, Murphy, Kronenberg, Spear, Ware: "T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7286-96, (2009) (PubMed).

Cheung, Steinberg, Oborne, Macauley, Fukuyama, Sanjo, DSouza, Norris, Pfeffer, Murphy, Kronenberg, Spear, Ware: "Unconventional ligand activation of herpesvirus entry mediator signals cell survival." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 15, pp. 6244-9, (2009) (PubMed).

Détails sur BTLA

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: BTLA (BTLA Produits)

Synonymes: anticorps BTLA, anticorps BTLA1, anticorps CD272, anticorps A630002H24, anticorps B and T lymphocyte associated, anticorps BTLA, anticorps Btla

Sujet: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints