Periostin anticorps (full length)

N° du produit ABIN1169103

Cet anticorps anti-Periostin est un anticorps Souris Monoclonal détectant Periostin dans WB, IHC et ELISA. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Periostin anticorps (full length) (ABIN1169103)

Antigène: Periostin (POSTN)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Periostin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: Stiny-1

Détail du produit anti-Periostin anticorps

Épitope: full length

Specificité: Recognizes human and mouse periostin.

Réactivité croisée: Humain, Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Full-length human periostin.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-Periostin (ABIN1169103)

Wang, Liu, Wang, Huang, Liu, Zhu, Cai, Fang, Lin, Yuan, Ouyang: "Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells." dans: PLoS ONE, Vol. 8, Issue 8, pp. e72962, (2013) (PubMed).

Ghajar, Peinado, Mori, Matei, Evason, Brazier, Almeida, Koller, Hajjar, Stainier, Chen, Lyden, Bissell: "The perivascular niche regulates breast tumour dormancy." dans: Nature cell biology, Vol. 15, Issue 7, pp. 807-17, (2013) (PubMed).

Détails sur Periostin

Antigène: Periostin (POSTN)

Autre désignation: Periostin

Sujet: Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

UniProt: Q15063